Veterinary products

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Colloidal silver based veterinary products

Mechanism of action of colloidal silver

The antibacterial activity of colloidal silver based veterinary products is based on the synergistic effect of colloidal silver particles and benzyldimethyl-[3-myristoylamine)-propyl]ammonium chloride molecules.

Silver particles are slowly oxidized by the oxygen present in the air, releasing silver ions which disrupt operation of transport proteins and enzymes of a pathogen’s electron transport chain (ETC) by penetrating the bacterial cell, interrupting translation and ultimately causing the cell’s death. Slow and controlled oxidation of silver particles is achieved due to them being stabilized with benzyldimethyl-[3-myristoylamine)-propyl]ammonium chloride, which is the key to the prolonged action of colloidal silver based veterinary products.

Benzyldimethyl-[3-myristoylamine)-propyl]ammonium chloride, being a typical cationic surfactant, has its own antibacterial activity – it loosens the cell membrane, disturbing its permeability. At the same time, benzyldimethyl-[3-myristoylamine)-propyl]ammonium chloride helps facilitate the delivery of silver ions inside the cell, enhancing their action.

Due to selective attachment of positively charged silver particles to the negatively charged outer membrane of a bacterial cell which creates high local concentration of silver ions around the cell wall of the pathogen cell, colloidal silver based veterinary products are very effective without any negative side effect on the tissues.

The anti-inflammatory effect of the products is based on the ability of colloidal silver particles to initiate production of anti-inflammatory cytokines and suppress production of proinflammatory mediators.

Colloidal silver initiates a biochemical cascade aimed at reducing inflammation even in areas with no direct contact with silver particles. Selective induction of apoptosis and a decrease in expression and activity of MMP-2 (matrix metalloproteinase-2), MMP-9, proinflammatory cytokines (TGF)-β and (TNF)-α can both be observed in tissues close to the areas treated with colloidal silver but not directly exposed to it. As a result, the processes initiated by colloidal silver affecting the top layers of skin and mucous membranes lead to a systemic decrease in inflammation, which is especially important for treatment of such diseases as bovine endometritis or pet gingivitis.

Safety of use

According to the results of numerous preclinical studies, colloidal silver based veterinary products can be assigned lowest toxicity class. Prolonged use of the product (for more than 10 days) at a dose 10 times higher than the recommended:

did not cause death of laboratory animals;

did not have any negative effect on their general condition;

did not lead to statistically significant changes in the concentration of hemoglobin, the number of erythrocytes, leukocytes, platelets;

did not affect the mass content of total protein, albumin, urea, creatinine in the blood serum of animals;

did not lead to statistically significant changes in the activity of the ALT and AST enzymes.

Pet treatment

Application of colloidal silver based veterinary products during pet treatment helps achieve:

a lasting antibacterial and antifungal effect;
a strong regenerative effect with respect to mucous membranes and skin;
a prominent anti-inflammatory effect when applied locally;
an immune system boost through oral administration.

The synergy between colloidal silver particles and benzyldimethyl-[3-myristoylamine)-propyl]ammonium chloride results in the strong antibacterial activity and pronounced wound healing effect, both achieved without causing pain or irritation. Colloidal silver based veterinary products can be used to treat pregnant animals, lactating animals or the offspring.

Due to their high therapeutic efficacy, colloidal silver based veterinary products outperform most modern antiseptics and preparations aimed at regeneration of skin and mucous membranes and can be seamlessly incorporated in the complex process of postoperative rehabilitation of immunocompromised animals.

Colloidal silver based veterinary products, applied as a part of the complex therapy of infectious and inflammatory diseases of bacterial, viral and mixed etiology, can significantly reduce the duration of treatment and help lower the dosages of antibacterial and antiviral drugs and immunostimulants, which as a result helps reduce the total chemotherapeutic load on the body of a weakened animal.

Colloidal silver based veterinary
products can be used for:

therapy and prevention of oral diseases (gingivitis, stomatitis);
therapy and prevention of ear diseases (otitis);
therapy and prevention of upper respiratory tract infections (rhinitis);
therapy and prevention of eye diseases (conjunctivitis);
antiseptic applications, wound treatment and antifungal treatment (dermatomycosis, dermatitis, burns, open wounds);
postoperative rehabilitation of cats and dogs;
treatment of genitourinary diseases (cystitis, urethritis, endometritis);
therapy and prevention of gastrointestinal diseases (enteritis of viral, bacterial and mixed etiology).

Cattle treatment

Colloidal silver based veterinary products used to treat bovine diseases:

are more effective at reducing inflammation and stimulating regeneration of the mucous membranes of the uterus and the udder compared to other existing products;
have a longer positive effect compared to traditional antiseptics;
do not irritate mucous membranes or the wound surface area;

contain components with low bioavailability which helps reduce the antibiotic load on the animal’s body;
make it possible not to reject meat or milk of an animal under treatment due to the absence of antibiotics;
are safe for pregnant animals, lactating animals or the offspring.

Colloidal silver based veterinary products can be used for:

therapy and prevention of postpartum endometritis (acute and chronic);
therapy and prevention of subclinical mastitis;
better treatment of catarrhal and purulent-catarrhal mastitis when combined with traditional antibiotics;
therapy of aseptic, infected and surgical wounds, abrasions, burns, ulcers and dermatitis.

Safety of use

Pet treatment

Colloidal silver based veterinary products can be used for:

Cattle treatment

Colloidal silver based veterinary products can be used for:

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Colloidal silver based veterinary
products can be used for: